Environmental & Molecular Toxicology

Jerry Hendricks

Professor Emeritus
Dept: EMT (FTNL-28645 E Hwy 34)
Ph.D. 1971, Colorado State University
Phone: 541-737-4193
Fax: 541-737-0497
jerry.hendricks@oregonstate.edu

Current research centers around the histopathology of chemically induced neoplasia in rainbow trout.  Specific research projects include: 1) Identifying natural inhibitors of carcinogenesis and understanding their mechanisms of action in rainbow trout; 2) Continued development of the rainbow trout as an alternate model system for toxicology and cancer research, emphasizing new exposure routes, timing of exposure to carcinogens and modifiers, temperature effects, dietary effects and histopathology of neoplastic development.

• TILTON, S.C., GERWICK, L.G., HENDRICKS, J.D., ROSATO, C.S., CORLEY-SMITH, G., GIVAN, S.A., BAILEY, G.S., BAYNE, C.J., and WILLIAMS, D.E. (2005). Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver. Toxicol Sci. 88(2):319-30.
• WILLIAM, D.E., BAILEY, G.S., REDDY A., HENDRICKS, J.D., OGANESIAN, A., ORNER, G.A., PEREIRA, C.B., and SWENBERG, J.A. (2003). The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters. Toxicol Pathol. 2003 Jan-Feb;31 Suppl:58-61.
• EL-ZAHR, C.R., ZHANG, Q., HENDRICKS, J.D., and CURTIS, L.R. (2002). Temperature-modulated carcinogenicity of 7,12-dimethylbenz[a]anthracene in rainbow trout. J Toxicol Environ Health A. 65(11):787-802.
• SPITSBERGEN, J.M., TSAI, H.W., REDDY, A., MILLER, T., ARBOGAST, D., HENDRICKS, J.D., BAILEY, G.S. (2000). Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N'-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages. Toxicol Pathol. 28(5):716-25.
• SPITSBERGEN, J.M., TSAI, H.W., REDDY, A., MILLER, T., ARBOGAST, D., HENDRICKS, J.D., BAILEY, G.S. (2000). Neoplasia in zebrafish (Danio rerio) treated with 7,12-dimethylbenz[a]anthracene by two exposure routes at different developmental stages. Toxicol Pathol. 28(5):705-15.
• REDDY, A.P., HARTTIG, U., BARTH, M.C., BAIRD, W.M., SCHIMERLIK, M., HENDRICKS, J.D., and BAILEY, G.S. (1999). Inhibition of dibenzo[a,l]pyrene-induced multi-organ carcinogenesis by dietary chlorophyllin in rainbow trout. Carcinogenesis. 20(10):1919-26.
  
• REDDY, A.P., SPITSBERGEN, J.M., MATHEWS, C., HENDRICKS, J.D., and BAILEY, G.S. (1999). Experimental hepatic tumorigenicity by environmental hydrocarbon dibenzo[a,l]pyrene. J Environ Pathol Toxicol Oncol. 18(4):261-9.
• OGANESIAN, A., HENDRICKS, J.D., PEREIRA, C.B., ORNER, G.A., BAILEY, G.S., and WILLIAMS, D.E. (1999). Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study. Carcinogenesis. 20(3):453-8.
• BAILEY, G.S., DASHWOOD, R., LOVELAND, P.M., PEREIRA, C., and HENDRICKS, J.D. (1998). Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout. Mutat Res. 399(2):233-44.
• DONOHOE, R.M., ZHANG, Q., SIDDENS, L.K., CARPENTER, H.M., HENDRICKS, J.D., and CURTIS, L.R. (1998). Modulation of 7,12-dimethylbenz[a]anthracene disposition and hepatocarcinogenesis by dieldrin and chlordecone in rainbow trout. J Toxicol Environ Health A. 54(3):227-42.
• ORNER, G.A., HENDRICKS, J.D., ARBOGAST, D. and WILLIAMS D.E. (1998). Modulation of aflaxtoxin B1 heptacarcinogenesis in trout by dehydroepiandrosterone:  Initiation/post-initiation and latency effects. Carcinogenesis 19,161-167.
  
• TROXEL, C.M., BUHLER, D.R., HENDRICKS, J.D. and BAILEY, G.S. (1997). CYP1A induction by β-naphthoflavone, Aroclor 1254 and 2,3,7,8-tetrachlorodibenzo-p-dioxin and its influence on aflaxtoxin B1 metabolism and DNA adduction in zebrafish (Danio rerio). Toxicol. Appl. Pharmacol. 146, 69-78.
  
• OGANESIAN, A., HENDRICKS, J.D. and WILLIAMS, D.E. (1997).  Long-term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model.  Canc. Lett. 118, 87-94
• CHENG, R., BRADFORD, S., BARNES, D., WILLIAMS, D., HENDRICKS, J. and BAILEY, G. (1997). Cloning, sequencing, and embryonic expression of an N-ras proto-oncogene isolated from an enriched zebrafish (Danio rerio) cDNA library.  Mol. Mar. Biol. Biotech. 6(1), 40-47.